Influenza A virus enhances ciliary activity and mucociliary clearance via TLR3 in airway epithelium
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چکیده
منابع مشابه
Linking increased airway hydration, ciliary beating, and mucociliary clearance through ENaC inhibition.
Airway dehydration causes mucus stasis and bacterial overgrowth in cystic fibrosis and chronic bronchitis (CB). Rehydration by hypertonic saline is efficacious but suffers from a short duration of action. We tested whether epithelial sodium channel (ENaC) inhibition would rehydrate normal and dehydrated airways to increase mucociliary clearance (MCC) over a significant time frame. For this, we ...
متن کاملPulmonary radioaerosol mucociliary clearance in primary ciliary dyskinesia.
Primary ciliary dyskinesia (PCD) is a genetic condition affecting one in 10 000–40 000 people from birth [1]; cilia fail to beat, and the airway clearance of mucus and debris is severely impaired. If untreated, this results in progressive lung infection leading to bronchiectasis and ultimately respiratory failure. Additionally, delayed diagnosis has implications for genetic counselling, appropr...
متن کاملMucociliary clearance, airway inflammation and nasal symptoms in urban motorcyclists
OBJECTIVES There is evidence that outdoor workers exposed to high levels of air pollution exhibit airway inflammation and increased airway symptoms. We hypothesized that these workers would experience increased airway symptoms and decreased nasal mucociliary clearance associated with their exposure to air pollution. METHODS In total, 25 non-smoking commercial motorcyclists, aged 18-44 years, ...
متن کامل[Airway calcium deposition and broncholithiasis in disorders of mucociliary clearance].
To the Editor: We read with interest the report by García Pachón et al1 regarding idiopathic chronic lithoptysis and the letter by Roig Vázquez et al2 on lithoptysis in a patient with primary ciliary dyskinesia (PCD). Complementing these observations, we recently completed an analysis of lithoptysis and airway calcification in a large cohort (n=142) of wellcharacterized PCD patients.3 We identi...
متن کاملHsp70 enhances influenza A virus polymerase activity
The role of heat shock protein 70 (Hsp70) in virus replication has been discussed for many viruses. The known suppressive role of Hsp70 in influenza virus replication is based on studies conducted in cells with various Hsp70 expression levels. In this study, we determined the role of Hsp70 in influenza virus replication in HeLa and HEK293T cells, which express Hsp70 constitutively. Co-immunopre...
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ژورنال
عنوان ژورنال: Respiratory Research
سال: 2020
ISSN: 1465-993X
DOI: 10.1186/s12931-020-01555-1